Satellite Cells In Skeletal Muscle Hypertrophy

The role of satellite cells in muscle hypertrophy has long been a debated issue.

Satellite cells in skeletal muscle hypertrophy.

Specific to skeletal muscle hypertrophy hgf activates satellite cells and may be responsible for causing satellite cells to migrate to the injured area 2. There was no change in satellite cells or mnd in the traditional endurance and control groups. These data are consistent with the hypothesis that testosterone administration induces skeletal muscle hypertrophy by promoting satellite cell replication and activation resulting in an increased number of myogenically committed satellite cells 23 34 36. Hikida et al 2000.

Hormones in skeletal muscle hypertrophy hormones are chemicals which organs secrete to initiate or regulate the activity of an organ or group of cells in another part of the body. These findings have led to a general consensus that satellite cell mediated myonuclear addition is likely an involved mechanism in promoting skeletal muscle hypertrophy and this hypothesis is further supported by studies which have illustrated high associations exist between fcsa and myonuclear number kadi et al 1999. Gradams uci edu satellite cells are small mononuclear cells found in close association with striated skeletal muscles cells myofibers. Satellite cell proliferation and skeletal muscle hypertrophy.

This together with the observation that during various models of muscle hypertrophy there is an activation of the muscle stem cells i e. In the late 1980s it was shown that proteins remain close to the myonucleus responsible for its synthesis giving. Following on from part 1 this article looks at the role of satellite cells in the muscle hypertrophy process. 1 department of physiology and biophysics medical science i d335 university of california irvine ca 92697 usa.

The role of satellite cells in muscle hypertrophy has long been a debated issue. Satellite cells lead to. The myonuclear number did not change in any group. An important unresolved question in skeletal muscle plasticity is whether satellite cells are necessary for muscle fiber hypertrophy.

To address this issue a novel mouse strain pax7 dta was created which enabled the conditional ablation of 90 of satellite cells in mature skeletal muscle following tamoxifen administration. In the late 1980s it was shown that proteins remain close to the myonucleus responsible for its synthesis giving rise to the idea of a nuclear domain. Through the stimulus overload adaptation cycle muscle tissue has the ability to produce more contractile force store higher levels of substrate improve. This is a major research finding alas at the molecular level of muscle which shows that skeletal muscle fiber hypertrophy begins to occur before the addition of new muscle nuclei see figure 1.